LLY-283 is the potent and selective SAM-competitive chemical probe for PRMT5. It inhibits PRMT5 enzyme activity with IC50 of 20 nM for methylation of an H4R3 derived peptide substrate, and shows greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets.
Molecular Weight:
342.35
Purity:
>99.0%
CAS Number:
[2040291-27-6]
Formula:
C17H18N4O4
Target:
PRMTs
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