A-196 is a potent selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively, and biochemically inhibits SUV4-20 in a substrate-competitive manner. In addition, A-196 is a first-in-class chemical probe for SUV4-20, which can be used to study the role of histone methyltransferases in genome integrity.
Molecular Weight:
359.25
Purity:
>99.0%
CAS Number:
[1982372-88-2]
Formula:
C18H16Cl2N4
Target:
Histone Methyltransferase
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