AS1269574 is a potent, orally active GPR119 agonist with an EC50 of 2.5 µM in HEK293 cells expressing human GPR119. AS1269574 activates the TRPA1 cation channel and stimulates glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induced pancreatic beta cells to secrete glucose-dependent insulin only under high glucose conditions. AS1269574 has potential for type 2 diabetes research.
Molecular Weight:
308.17
Purity:
>99%
CAS Number:
[330981-72-1]
Formula:
C13H14BrN3O
Target:
GPR/FFAR
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