Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3alpha/beta inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/beta-catenin signaling pathway activator.
Molecular Weight:
574.72
Purity:
>99.0%
CAS Number:
[1782235-14-6]
Formula:
C22H18Cl2N8.3HCl
Target:
GSK-3
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