YK 3-237 is a boronic acid chalcone analog of combretastatin a4 (CA-4) and a SIRT1 activator that targets mutant p53. YK 3-237 can reduce the acetylation of mutant p53 protein by activating the SIRT1 enzyme, resulting in a significant decrease in the level of mutant p53 protein. YK-3-237 showed antiproliferative activity against tumor cells containing mutant p53 protein.
Molecular Weight:
372.18
Purity:
>99%
CAS Number:
[1215281-19-8]
Formula:
C19H21BO7
Target:
Sirtuin
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