KT 5720 is a specific, reversible, ATP-competitive, cell-permeable protein kinase A (PKA) inhibitor with an IC50 value of 3.3 µM, which effectively reverses MDR1-mediated multidrug resistance and reduces excitability of dorsal root ganglion (DRG) neurons by attenuating the activity of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels and decreasing the intracellular Ca2+ concentration. ) neurons by reducing hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel activity and intracellular Ca2+ concentration. It can be used in the study of hematologic malignancies and diseases associated with HCN and DRG neurons.
Molecular Weight:
537.61
Purity:
>98%
CAS Number:
[108068-98-0]
Formula:
C32H31N3O5
Target:
PKA
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