PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-beta signaling inhibitor.
Molecular Weight:
532.51
Purity:
>99.0%
CAS Number:
[192705-80-9]
Formula:
C26H35Cl2N7O
Target:
Others
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