IMR-1 is a first-in-class, cell-permeable inhibitor of the Notch transcription activation complex, with an IC50 of 26 µM. IMR-1 prevents Maml1 from recruiting to the Notch ternary complex (NTC) in chromatin, inhibits transcription of Notch target genes, and has antitumor activity.
Molecular Weight:
353.41
Purity:
>98.5%
CAS Number:
[310456-65-6]
Formula:
C15H15NO5S2
Target:
Notch
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