BRCA1 Antibody - N-terminal region

Product Overview

• Article Name: BRCA1 Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP30434_P050
• Supplier Catalog Number: ARP30434_P050
• Alternative Catalog Number: ASB-ARP30434_P050-25UL,ASB-ARP30434_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Canine, Equine, Human, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human BRCA1
• Alternative Names: IRIS, PSCP, BRCAI, BRCC1, FANCS, PNCA4, RNF53, BROVCA1, PPP1R53

Product Description

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. BRCA1 acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. BRCA1 plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is involved in transcriptional regulation of P21 in response to DNA damage. BRCA1 is also required for FANCD2 targeting to sites of DNA damage.It may function as a transcriptional regulator. BRCA1 inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 76kDa
• NCBI: 672
• UniProt: P38398
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.