MXI1 Antibody - middle region
Catalog Number:
ASB-ARP31403_P050
- Images (7)
| Article Name: | MXI1 Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP31403_P050 |
| Supplier Catalog Number: | ARP31403_P050 |
| Alternative Catalog Number: | ASB-ARP31403_P050-25UL,ASB-ARP31403_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Canine, Guinea pig, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human MXI1 |
| Alternative Names: | MXI, MAD2, MXD2, bHLHc11 |
| Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The MXI1 gene encodes a transcriptional repressor protein thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in MXI1 are frequently found in patients with prostate tumors.Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. |
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25 ug of the indicated Mouse whole tissue extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. |
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Rabbit Anti-MXI1 Antibody Catalog Number: ARP31403 Paraffin Embedded Tissue: Human Lung Cellular Data: Epithelial cells of bronchiole Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X |
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WB Suggested Anti-MXI1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Human brain |
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Host: Mouse Target Name: MXI1 Sample Tissue: Mouse Brain Antibody Dilution: 1ug/ml |
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Host: Rabbit Target: MXI1 Positive control (+): Mouse Brain (M-BR) Negative control (-): Mouse Kidney (M-KI) Antibody concentration: 3ug/ml |
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IHC Suggested Anti-MXI1 antibody Titration: 5ug/ ml Positive Control: Lung, respiratory epithelium |
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MXI1 antibody - middle region (ARP31403_P050) in Human brain using Western Blot |
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