PAX3 Antibody - N-terminal region

Product Overview

• Article Name: PAX3 Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP32445_P050
• Supplier Catalog Number: ARP32445_P050
• Alternative Catalog Number: ASB-ARP32445_P050-25UL,ASB-ARP32445_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Yeast
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PAX3
• Alternative Names: WS1, WS3, CDHS, HUP2

Product Description

PAX3 is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2,13)(q35,q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma.This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2,13)(q35,q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2,13)(q35,q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 53kDa
• NCBI: 5077
• UniProt: Q494Z3
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

WB Suggested Anti-PAX3 Antibody Titration: 0.2-1 ug/ml
Positive Control: Hela cell lysate

Lanes:
Lane1: 20ug RH30 lysate
Lane2: 20ug RH30 lysate
Lane3: 20ug RH41 lysate
Lane4: 20ug RH41 lysate
Primary Antibody Dilution:
1:1000
Secondary Antibody:
Donkey anti-rabbit HRP
Secondary Antibody Dilution:
1:4000
Gene Name:
PAX3
Submitted by:
Dr Joanna Selfe, Institute of Cancer Research

Host: Mouse
Target Name: PAX3
Sample Tissue: Mouse Small Intestine
Antibody Dilution: 1ug/ml

Host: Rabbit
Target Name: PAX3
Sample Tissue: Human Jurkat Whole Cell
Antibody Dilution: 1ug/ml

PAX3 antibody - N-terminal region (ARP32445_P050) in Human HeLa using Western Blot