AIRE Antibody - N-terminal region

Product Overview

• Article Name: AIRE Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP32650_P050
• Supplier Catalog Number: ARP32650_P050
• Alternative Catalog Number: ASB-ARP32650_P050-25UL,ASB-ARP32650_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: IHC, WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE
• Alternative Names: APS1, APSI, PGA1, AIRE1, APECED

Product Description

The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 58kDa
• NCBI: 326
• UniProt: O43918
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

Rabbit Anti-AIRE Antibody
Catalog Number: ARP32650
Paraffin Embedded Tissue: Human Kidney
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

WB Suggested Anti-AIRE Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Human Liver

AIRE antibody - N-terminal region (ARP32650_P050) validated by WB using human LCL at 1:1000.

Host: Rabbit
Target Name: AIRE
Sample Tissue: Mouse Skeletal Muscle
Antibody Dilution: 1ug/ml

Host: Mouse
Target Name: AIRE
Sample Tissue: Mouse Skeletal Muscle
Antibody Dilution: 1ug/ml

AIRE antibody - N-terminal region (ARP32650_P050) in Human Liver using Western Blot