PLCG1 Antibody - C-terminal region (ARP33086_P050), Rabbit, Polyclonal

Product Overview

• Article Name: PLCG1 Antibody - C-terminal region (ARP33086_P050), Rabbit, Polyclonal
• Biozol Catalog Number: ASB-ARP33086_P050
• Supplier Catalog Number: ARP33086_P050
• Alternative Catalog Number: ASB-ARP33086_P050-100UL, ASB-ARP33086_P050-25UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PLCG1
• Alternative Names: PLC1, NCKAP3, PLC-II, PLC148, PLCgamma1

Product Description

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 141 kDa
• NCBI: 5335
• UniProt: P19174
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.