CLDN16 Antibody - C-terminal region
Catalog Number:
ASB-ARP33632_P050
- Images (5)
| Article Name: | CLDN16 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP33632_P050 |
| Supplier Catalog Number: | ARP33632_P050 |
| Alternative Catalog Number: | ASB-ARP33632_P050-25UL,ASB-ARP33632_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Bovine, Canine, Equine, Human, Mouse, Porcine, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human CLDN16 |
| Alternative Names: | HOMG3, PCLN1 |
| Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-16, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in the corresponding gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure.Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
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WB Suggested Anti-CLDN16 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human kidney |
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Host: Mouse Target Name: CLDN16 Sample Tissue: Mouse Kidney Antibody Dilution: 1ug/ml |
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Host: Rabbit Target Name: CLDN16 Sample Tissue: Mouse Liver Antibody Dilution: 3ug/ml |
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Host: Rabbit Target: CLDN16 Positive control (+): Human Liver (LI) Negative control (-): 293T Cell Lysate (2T) Antibody concentration: 1ug/ml |
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CLDN16 antibody - C-terminal region (ARP33632_P050) in Human kidney using Western Blot |
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