KCNN3 Antibody - C-terminal region

Product Overview

• Article Name: KCNN3 Antibody - C-terminal region
• Biozol Catalog Number: ASB-ARP35097_P050
• Supplier Catalog Number: ARP35097_P050
• Alternative Catalog Number: ASB-ARP35097_P050-25UL,ASB-ARP35097_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: IHC, WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KCNN3
• Alternative Names: SK3, ZLS3, hSK3, SKCA3, KCa2.3

Product Description

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 81kDa
• NCBI: 3782
• UniProt: Q9UGI6
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

Sample Type:
Rhesus macaque spinal cordPrimary Antibody Dilution:
1:300Secondary Antibody:
Donkey anti Rabbit 488Secondary Antibody Dilution:
1:500Color/Signal Descriptions:
Green: KCNN3Gene Name:
KCNN3Submitted by:
Timur Mavlyutov, Ph. D., Department of Pharmacology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706

Rabbit Anti-KCNN3 Antibody
Catalog Number: ARP35097_P050
Formalin Fixed Paraffin Embedded Tissue: Human Adult heart
Observed Staining: Membrane
Primary Antibody Concentration: 1:600
Secondary Antibody: Donkey anti-Rabbit-Cy2/3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 a€'' 2.0 sec
Protocol located in Reviews and Data.

WB Suggested Anti-KCNN3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Daudi cell lysateKCNN3 is supported by BioGPS gene expression data to be expressed in Daudi

KCNN3 antibody - C-terminal region (ARP35097_P050) validated by WB using Mouse kidney, Whole brain lysate at 2 ug/ml.

Host: Rabbit
Target Name: KCNN3
Sample Tissue: Human THP-1 Whole Cell
Antibody Dilution: 1ug/ml

Host: Rabbit
Target Name: KCNN3
Sample Tissue: Human MCF7 Whole Cell
Antibody Dilution: 0.5ug/ml

Host: Rabbit
Target Name: KCNN3
Sample Tissue: Human 293T Whole Cell
Antibody Dilution: 1ug/ml

KCNN3 antibody - C-terminal region (ARP35097_P050) in Human Daudi using Western Blot