CBL Antibody - C-terminal region
Catalog Number:
ASB-ARP35761_P050
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| Article Name: | CBL Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP35761_P050 |
| Supplier Catalog Number: | ARP35761_P050 |
| Alternative Catalog Number: | ASB-ARP35761_P050-25UL,ASB-ARP35761_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human CBL |
| Alternative Names: | CBL2, NSLL, C-CBL, RNF55, FRA11B |
| This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. |
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