SIAH1 Antibody - C-terminal region

Product Overview

• Article Name: SIAH1 Antibody - C-terminal region
• Biozol Catalog Number: ASB-ARP38212_T100
• Supplier Catalog Number: ARP38212_T100
• Alternative Catalog Number: ASB-ARP38212_T100-25UL,ASB-ARP38212_T100-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: IHC, WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SIAH1
• Alternative Names: SIAH1A

Product Description

SIAH1 is a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinsons disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterizedThis gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinsons disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Product Properties

• Clonality: Polyclonal
• Concentration: 1.0 mg/ml
• Molecular Weight: 31kDa
• NCBI: 6477
• UniProt: Q8IUQ4
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

Liver

WB Suggested Anti-SIAH1 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:312500
Positive Control: Human Placenta

Lanes:
Lane1: 50 ug human HEK-293T lysate
Primary Antibody Dilution:
1:1000
Secondary Antibody:
Anti-rabbit-IgG
Secondary Antibody Dilution:
1:5000
Gene Name:
SIAH1
Submitted by:
Peter Brand & Dr. Oliver Kramer, Institute for Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich-Schiller University Jena
SIAH1 is strongly supported by BioGPS gene expression data to be expressed in Human HEK293T cells

Host: Rabbit
Target: SIAH1
Positive control (+): Mouse Brain (M-BR)
Negative control (-): Mouse Pancreas (M-PA)
Antibody concentration: 1ug/ml

SIAH1 antibody - C-terminal region (ARP38212_T100) in Human Placenta using Western Blot