RBM5 Antibody - N-terminal region

Product Overview

• Article Name: RBM5 Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP38684_P050
• Supplier Catalog Number: ARP38684_P050
• Alternative Catalog Number: ASB-ARP38684_P050-25UL,ASB-ARP38684_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Yeast
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RBM5
• Alternative Names: G15, H37, RMB5, LUCA15, LUCA-15

Product Description

RBM5 is a component of the spliceosome A complex.It regulates alternative splicing of a number of mRNAs. RBM5 may modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5 and 3 splice sites of the intron. RBM5 may both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, RBM5 promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 92kDa
• NCBI: 10181
• UniProt: P52756
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

Rabbit Anti-RBM5 antibody
Catalog Number: ARP38684
Formalin Fixed Paraffin Embedded Tissue: Human Kidney
Primary antibody Concentration: 1:100
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20x
Exposure Time: 0.5-2.0sec

WB Suggested Anti-RBM5 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysateRBM5 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells

Human HepG2

Host: Rabbit
Target: RBM5
Positive control (+): Human Lung (LU)
Negative control (-): Human Liver (LI)
Antibody concentration: 1ug/ml

RBM5 antibody - N-terminal region (ARP38684_P050) in Human HepG2 using Western Blot