NR4A2 Antibody - N-terminal region

Product Overview

• Article Name: NR4A2 Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP38753_P050
• Supplier Catalog Number: ARP38753_P050
• Alternative Catalog Number: ASB-ARP38753_P050-25UL,ASB-ARP38753_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: IHC, WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NR4A2
• Alternative Names: NOT, RNR1, HZF-3, NURR1, TINUR

Product Description

NR4A2 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. The protein may act as a transcription factor. Mutations in NR4A2 gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of NR4A2 gene may be associated with rheumatoid arthritis.This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 66kDa
• NCBI: 4929
• UniProt: P43354
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

Immunohistochemistry of formalin-fixed, paraffin-embedded human adrenal tissue after heat-induced antigen retrieval. NR4A2 Antibody (ARP38753_P050) concentration 5 ug/ml.

Immunohistochemistry of formalin-fixed, paraffin-embedded human kidney tissue after heat-induced antigen retrieval. NR4A2 Antibody (ARP38753_P050) concentration 5 ug/ml.

WB Suggested Anti-NR4A2 Antibody Titration: 1 ug/ml
Positive Control: Hela cell lysate

Lanes:
Lane 1: Nuclear fraction from mouse substantia nigra
Lane 2: Nuclear fraction from mouse substantia nigra
Lane 3: Nuclear fraction from mouse cortex
Lane 4: Nuclear fraction from mouse cortex
Primary Antibody Dilution:
1:400
Secondary Antibody:
Goat anti rabbit-HRP
Secondary Antibody Dilution:
1:10,000
Gene Name:
NR4A2
Submitted by:
Sorce Silvia, University of Zurich

NR4A2 antibody - N-terminal region (ARP38753_P050) in Human HeLa using Western Blot