ARNT2 Antibody - N-terminal region
Catalog Number:
ASB-ARP39146_P050
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| Article Name: | ARNT2 Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-ARP39146_P050 |
| Supplier Catalog Number: | ARP39146_P050 |
| Alternative Catalog Number: | ASB-ARP39146_P050-25UL,ASB-ARP39146_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N-terminal region of Human ARNT2 |
| Alternative Names: | WEDAS, bHLHe1 |
| This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. |
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