NUP98 Antibody - N-terminal region

Article Name:	NUP98 Antibody - N-terminal region
Biozol Catalog Number:	ASB-ARP39251_P050
Supplier Catalog Number:	ARP39251_P050
Alternative Catalog Number:	ASB-ARP39251_P050-25UL,ASB-ARP39251_P050-100UL
Manufacturer:	Aviva
Host:	Rabbit
Category:	Proteine/Peptide
Application:	IF, WB
Species Reactivity:	Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
Immunogen:	The immunogen is a synthetic peptide directed towards the N terminal region of human NUP98
Alternative Names:	ADIR2, NUP96, NUP196, Nup98-96

The nuclear pore complex (NPC) is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants, however, not all variants have been fully described.

Clonality:	Polyclonal
Concentration:	0.5 mg/ml
Molecular Weight:	196kDa
NCBI:	4928
UniProt:	P52948-5
Form:	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

	Host: Rabbit Target Name: NUP98 Sample Tissue: Human THP-1 Whole Cell Antibody Dilution: 5ug/ml
	Host: Rabbit Target Name: NUP98 Sample Tissue: Human A549 Whole Cell Antibody Dilution: 3ug/ml
	Immunofluorescence -- Sample Type: HeLa cellsDilution: 2ug/mL
	WB Suggested Anti-NUP98 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Transfected 293T
	NUP98 Antibody - N-terminal region (ARP39251_P050) in Human THP-1 Whole Cell using Western Blot