NOTCH1 Antibody - middle region
Catalog Number:
ASB-ARP39295_P050
- Images (8)
| Article Name: | NOTCH1 Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP39295_P050 |
| Supplier Catalog Number: | ARP39295_P050 |
| Alternative Catalog Number: | ASB-ARP39295_P050-25UL,ASB-ARP39295_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rat, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human NOTCH1 |
| Alternative Names: | hN1, AOS5, TAN1, AOVD1 |
| NOTCH1 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
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Rabbit Anti-NOTCH1 Antibody Catalog Number: ARP39295_P050 Formalin Fixed Paraffin Embedded Tissue: Human Lung Tissue Observed Staining: Plasma membrane Primary Antibody Concentration: 1:100 Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec |
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WB Suggested Anti-NOTCH1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: 293T cell lysate |
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25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. Full length NOTCH1 (~273 kDa) is not shown in this experiment, cleavage products of NOTCH1 are detected including the NOTCH Intracellular Domain at 88 kDa. |
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Host: Rabbit Target Name: NOTCH1 Sample Tissue: Human PANC1 Whole Cell Antibody Dilution: 1ug/ml |
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Host: Rabbit Target Name: NOTCH1 Sample Tissue: Human HepG2 Whole Cell Antibody Dilution: 1ug/ml |
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Host: Rabbit Target Name: NOTCH1 Sample Tissue: Human U937 Whole Cell Antibody Dilution: 1ug/ml |
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Host: Rabbit Target Name: NOTCH1 Sample Tissue: Human HT1080A Whole Cell Antibody Dilution: 1ug/ml |
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