PRMT5 Antibody - N-terminal region

Product Overview

• Article Name: PRMT5 Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP40185_T100
• Supplier Catalog Number: ARP40185_T100
• Alternative Catalog Number: ASB-ARP40185_T100-25UL,ASB-ARP40185_T100-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: IHC, WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT5
• Conjugation: Unconjugated
• Alternative Names: HSL7, JBP1, SKB1, IBP72, SKB1Hs, HRMT1L5

Product Description

PRMT5 methylates specific arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3 to monomethylarginine and to symmetrical dimethylarginines (sDMAs). It methylates SUPT5H. PRMT5 plays a role in the assembly of snRNP core particles and may play a role in cytokine-activated transduction pathways. It negatively regulates cyclin E1 promoter activity and cellular proliferation and May regulate the SUPT5H transcriptional elongation properties. It may be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. PRMT5 methylates histone H2A/H4 Arg-3 during germ cell development and methylates histone H3 Arg-8, which may repress transcription.

Product Properties

• Clonality: Polyclonal
• Concentration: 1.0 mg/ml
• Molecular Weight: 68kDa
• NCBI: 10419
• UniProt: O14744
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

Rabbit Anti-PRMT5 Antibody
Catalog Number: ARP40185
Paraffin Embedded Tissue: Human Kidney
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

Rabbit Anti-PRMT5 Antibody
Catalog Number: ARP40185
Paraffin Embedded Tissue: Human Lung
Cellular Data: Alveolar cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

WB Suggested Anti-PRMT5 Antibody Titration: 2.5ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysatePRMT5 is supported by BioGPS gene expression data to be expressed in Jurkat

PRMT5 antibody - N-terminal region (ARP40185_T100) in Human Jurkat using Western Blot