PCBP2 Antibody - middle region
Catalog Number:
ASB-ARP40568_T100
- Images (5)
| Article Name: | PCBP2 Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP40568_T100 |
| Supplier Catalog Number: | ARP40568_T100 |
| Alternative Catalog Number: | ASB-ARP40568_T100-25UL,ASB-ARP40568_T100-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Equine, Guinea pig, Human, Mouse, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human PCBP2 |
| Alternative Names: | HNRPE2, HNRNPE2, hnRNP-E2 |
| PCBP2 appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. This protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes.The protein encoded by this gene appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 intronless gene which has similar functions. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. It also has two processed pseudogenes PCBP2P1 and PCBP2P2. There are presently two alternatively spliced transcript variants described for this gene. |
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Rabbit Anti-PCBP2 Antibody Catalog Number: ARP40568 Paraffin Embedded Tissue: Human Lung Cellular Data: Alveolar cells Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X |
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WB Suggested Anti-PCBP2 Antibody Titration: 1.25ug/ml Positive Control: Jurkat cell lysateThere is BioGPS gene expression data showing that PCBP2 is expressed in Jurkat |
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Host: Rabbit Target Name: PCBP2 Sample Tissue: Human Jurkat Antibody Dilution: 1.0ug/ml |
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Host: Mouse Target Name: PCBP2 Sample Tissue: Mouse Pancreas Antibody Dilution: 1ug/ml |
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PCBP2 antibody - middle region (ARP40568_T100) in Human Jurkat using Western Blot |
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