NEDD4L Antibody - middle region

Product Overview

• Article Name: NEDD4L Antibody - middle region
• Biozol Catalog Number: ASB-ARP43192_P050
• Supplier Catalog Number: ARP43192_P050
• Alternative Catalog Number: ASB-ARP43192_P050-25UL,ASB-ARP43192_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NEDD4L
• Alternative Names: RSP5, PVNH7, NEDD4-2, NEDD4.2, hNEDD4-2

Product Description

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 110 kDa
• NCBI: 23327
• UniProt: Q96PU5-5
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

WB Suggested Anti-NEDD4L Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: PANC1 cell lysate

Human cystic fibrosis epithelial

ARP43192-QC73365-190627-WB-image.jpg

Host: Rabbit
Target Name: NEDD4L
Sample Tissue: Human Hela Whole Cell
Antibody Dilution: 3ug/ml

NEDD4L antibody - middle region (ARP43192_P050) in Human PANC1 using Western Blot