SGCB Antibody - middle region

Product Overview

• Article Name: SGCB Antibody - middle region
• Biozol Catalog Number: ASB-ARP44244_P050
• Supplier Catalog Number: ARP44244_P050
• Alternative Catalog Number: ASB-ARP44244_P050-25UL,ASB-ARP44244_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SGCB
• Alternative Names: A3b, SGC, LGMD2E, LGMDR4

Product Description

SGCB is a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix.The dystrophin-glycoprotein complex (DGC) is a multisubunit protein complex that spans the sarcolemma and provides structural linkage between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. There are 3 main subcomplexes of the DGC: the cytoplasmic proteins dystrophin (DMD, MIM 300377) and syntrophin (SNTA1, MIM 601017), the alpha- and beta-dystroglycans (see MIM 128239), and the sarcoglycans (see, e.g., SGCA, MIM 600119) (Crosbie et al., 2000 [PubMed 10942431]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1235 BC020709.1 1-1235 1236-1833 U31116.1 1257-1854 1834-4229 AK094731.1 47-2442

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 35 kDa
• NCBI: 6443
• UniProt: Q16585
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

WB Suggested Anti-SGCB Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human heart

Host: Rabbit
Target Name: SGCB
Sample Type: Human Fetal Heart
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target: SGCB
Positive control (+): Human heart muscle
Negative control (-): HeLa (HL)
Antibody concentration: 1ug/ml

25 ug of the indicated Mouse whole cell extracts was loaded onto a 12% SDS-PAGE gel. 2 ug/mL of the antibody was used in this experiment. Recommended dilution of antibody is 1-3 ug/mL. Multiple modified and unmodified isoforms can be recognized by this antibody.

25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 2 ug/mL of the antibody was used in this experiment. Recommended dilution of antibody is 1-3 ug/mL. Multiple isoforms can be recognized by this antibody.

SGCB antibody - middle region (ARP44244_P050) in Human Heart using Western Blot