ACVR1 Antibody - N-terminal region

Article Name:	ACVR1 Antibody - N-terminal region
Biozol Catalog Number:	ASB-ARP45039_P050
Supplier Catalog Number:	ARP45039_P050
Alternative Catalog Number:	ASB-ARP45039_P050-25UL,ASB-ARP45039_P050-100UL
Manufacturer:	Aviva
Host:	Rabbit
Category:	Proteine/Peptide
Application:	WB
Species Reactivity:	Bovine, Equine, Goat, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat
Immunogen:	The immunogen is a synthetic peptide directed towards the N terminal region of human ACVR1
Alternative Names:	FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2

Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Clonality:	Polyclonal
Concentration:	0.5 mg/ml
Molecular Weight:	55kDa
NCBI:	90
UniProt:	Q04771
Form:	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

	WB Suggested Anti-ACVR1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Transfected 293T
	Host: Rabbit Target Name: ACVR1 Sample Type: Human Fetal Heart Antibody Dilution: 1.0ug/ml
	Host: Rabbit Target Name: ACVR1 Sample Type: Human Fetal Lung Antibody Dilution: 1.0ug/ml
	Host: Mouse Target Name: ACVR1 Sample Tissue: Mouse Testis Antibody Dilution: 1ug/ml
	ACVR1 antibody - N-terminal region (ARP45039_P050) in Transfected 293T using Western Blot