ACVR1 Antibody - N-terminal region

Product Overview

• Article Name: ACVR1 Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP45040_P050
• Supplier Catalog Number: ARP45040_P050
• Alternative Catalog Number: ASB-ARP45040_P050-25UL,ASB-ARP45040_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: IHC, WB
• Species Reactivity: Bovine, Canine, Equine, Goat, Guinea pig, Human, Mouse, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ACVR1
• Alternative Names: FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2

Product Description

Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 57 kDa
• NCBI: 90
• UniProt: Q04771
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment.

Human Muscle

WB Suggested Anti-ACVR1 Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysate

Host: Rabbit
Target Name: ACVR1
Sample Tissue: Mouse Testis
Antibody Dilution: 1ug/ml

ACVR1 antibody - N-terminal region (ARP45040_P050) in Human HepG2 using Western Blot