ATP2A2 Antibody - C-terminal region

Product Overview

• Article Name: ATP2A2 Antibody - C-terminal region
• Biozol Catalog Number: ASB-ARP45159_P050
• Supplier Catalog Number: ARP45159_P050
• Alternative Catalog Number: ASB-ARP45159_P050-25UL,ASB-ARP45159_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: IHC, WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ATP2A2
• Alternative Names: DD, DAR, ATP2B, SERCA2

Product Description

ATP2A2 is one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in two transcript variants encoding different isoforms.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 115kDa
• NCBI: 488
• UniProt: P16615
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

Sample Type:
Rhesus macaque spinal cordPrimary Antibody Dilution:
1:300Secondary Antibody:
Donkey anti Rabbit 488Secondary Antibody Dilution:
1:500Color/Signal Descriptions:
Green: ATP2A2Gene Name:
APLP2Submitted by:
Timur Mavlyutov, Ph. D., Department of Pharmacology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706

WB Suggested Anti-ATP2A2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: MCF7 cell lysate

Host: Mouse
Target Name: ATP2A3
Sample Tissue: Mouse Liver
Antibody Dilution: 1ug/ml

ATP2A2 antibody - C-terminal region (ARP45159_P050) in Human MCF-7 using Western Blot