TAPBP Antibody - C-terminal region

Product Overview

• Article Name: TAPBP Antibody - C-terminal region
• Biozol Catalog Number: ASB-ARP45437_P050
• Supplier Catalog Number: ARP45437_P050
• Alternative Catalog Number: ASB-ARP45437_P050-25UL,ASB-ARP45437_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: IHC, WB
• Species Reactivity: Bovine, Human, Porcine, Sheep
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TAPBP
• Alternative Names: TPN, TAPA, TPSN, NGS17

Product Description

TAPBP is a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum.This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 46kDa
• NCBI: 6892
• UniProt: O15533
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

ARP45437-QC15524-41600-WB-image.jpg

Human Skin

Rabbit Anti-TAPBP Antibody
Catalog Number: ARP45437_P050
Formalin Fixed Paraffin Embedded Tissue: Human Adult liver
Observed Staining: Cytoplasmic
Primary Antibody Concentration: 1:600
Secondary Antibody: Donkey anti-Rabbit-Cy2/3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 a€'' 2.0 sec
Protocol located in Reviews and Data.

WB Suggested Anti-TAPBP Antibody Titration: 0.5ug/ml
Positive Control: HepG2 cell lysate

WB Suggested Anti-TAPBP antibody Titration: 1 ug/mL
Sample Type: Human liver

TAPBP antibody - C-terminal region (ARP45437_P050) in Human HepG2 using Western Blot