OSMR Antibody - N-terminal region

Product Overview

• Article Name: OSMR Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP46395_P050
• Supplier Catalog Number: ARP46395_P050
• Alternative Catalog Number: ASB-ARP46395_P050-25UL,ASB-ARP46395_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Bovine, Canine, Human
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human OSMR
• Alternative Names: OSMRB, PLCA1, IL-31RB, OSMRbeta, IL-31R-beta

Product Description

Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF.Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 111 kDa
• NCBI: 9180
• UniProt: Q99650
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

WB Suggested Anti-OSMR Antibody Titration: 0.2-1 ug/ml
Positive Control: HT1080 cell lysateOSMR is supported by BioGPS gene expression data to be expressed in HT1080

25 ug of the indicated Human whole cell extracts was loaded onto a 6-18% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. In addition to the canonical isoform at 111 kDa, the peptide sequence is present in isoforms of ~88 kDa, ~64 kDa, and ~40 kDa. The protein may further by modified by glycosylation and/or phosphorylation.

Host: Rabbit
Target Name: OSMR
Sample Tissue: Human A549 Whole Cell
Antibody Dilution: 1ug/ml

OSMR antibody - N-terminal region (ARP46395_P050) in Human HT1080 using Western Blot