FBXW7 Antibody - C-terminal region, Rabbit, Polyclonal

Product Overview

• Article Name: FBXW7 Antibody - C-terminal region, Rabbit, Polyclonal
• Biozol Catalog Number: ASB-ARP47419_P050
• Supplier Catalog Number: ARP47419_P050
• Alternative Catalog Number: ASB-ARP47419_P050-25UL, ASB-ARP47419_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Antikörper
• Application: IHC, WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human FBXW7
• Alternative Names: AGO, CDC4, FBW6, FBW7, hAgo, FBX30, FBXW6, SEL10, hCdc4, FBXO30, SEL-10

Product Description

FBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines, implicating the genes potential role in the pathogenesis of human cancers.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 80 kDa
• NCBI: 55294
• UniProt: Q969H0-4
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.