NP Antibody - middle region

Product Overview

• Article Name: NP Antibody - middle region
• Biozol Catalog Number: ASB-ARP48474_P050
• Supplier Catalog Number: ARP48474_P050
• Alternative Catalog Number: ASB-ARP48474_P050-25UL,ASB-ARP48474_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NP
• Alternative Names: NP, PUNP, PRO1837

Product Description

Defects in NP are the cause of nucleoside phosphorylase deficiency (NP deficiency). It leads to a severe T-cell immunodeficiency with neurologic disorder in children. The specific function of NP is not yet known.This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 32kDa
• NCBI: 4860
• UniProt: P00491
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

WB Suggested Anti-NP Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: THP-1 cell lysate

Host: Rabbit
Target Name: PNP
Sample Type: MCF7
Antibody Dilution: 1.0ug/mlPNP is supported by BioGPS gene expression data to be expressed in MCF7

Host: Rabbit
Target Name: PNP
Sample Type: Human Fetal Liver
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: PNP
Sample Type: Human Adult Placenta
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: PNP
Sample Tissue: Human OVCAR-3 Whole Cell
Antibody Dilution: 1ug/ml

NP antibody - middle region (ARP48474_P050) in Human THP-1 using Western Blot