SIGIRR Antibody - C-terminal region

Product Overview

• Article Name: SIGIRR Antibody - C-terminal region
• Biozol Catalog Number: ASB-ARP49664_P050
• Supplier Catalog Number: ARP49664_P050
• Alternative Catalog Number: ASB-ARP49664_P050-25UL,ASB-ARP49664_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: IHC, WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rat, Zebrafish
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SIGIRR
• Alternative Names: TIR8, IL-1R8

Product Description

SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 25kDa
• NCBI: 59307
• UniProt: Q6IA17
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

Liver

WB Suggested Anti-SIGIRR Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate

Host: Rabbit
Target Name: SIGIRR
Sample Type: Human Adult Placenta
Antibody Dilution: 1.0ug/ml

SIGIRR antibody - C-terminal region (ARP49664_P050) in Hum. Adult Placenta using Western Blot