HYAL1 Antibody - N-terminal region

Product Overview

• Article Name: HYAL1 Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP50812_P050
• Supplier Catalog Number: ARP50812_P050
• Alternative Catalog Number: ASB-ARP50812_P050-25UL,ASB-ARP50812_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: IHC, WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HYAL1
• Alternative Names: MPS9, NAT6, LUCA1, HYAL-1

Product Description

HYAL1 is a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. HYAL1 is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for HYAL1.This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 45kDa
• NCBI: 3373
• UniProt: Q12794
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

Immunohistochemistry with breast cancer tissue tissue

Immunohistochemistry with Human Liver cell lysate tissue at an antibody concentration of 5.0ug/ml using anti-HYAL1 antibody (ARP50812_P050)

HYAL1 antibody - N-terminal region (ARP50812_P050) validated by WB using HepG2 cell lysate at 1ug/ml.HYAL1 is supported by BioGPS gene expression data to be expressed in HepG2

Host: Rabbit
Target Name: HYAL1
Sample Type: Human Fetal Brain
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: HYAL1
Sample Type: Human Fetal Lung
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target: HYAL1
Positive control (+): HepG2 (HG)
Negative control (-): Human Ovary (OV)
Antibody concentration: 0.5ug/ml

HYAL1 antibody - N-terminal region (ARP50812_P050) in Human HepG2 using Western Blot