RBBP8 Antibody - C-terminal region

Product Overview

• Article Name: RBBP8 Antibody - C-terminal region
• Biozol Catalog Number: ASB-ARP50887_P050
• Supplier Catalog Number: ARP50887_P050
• Alternative Catalog Number: ASB-ARP50887_P050-25UL,ASB-ARP50887_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Porcine, Rabbit
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human RBBP8
• Alternative Names: RIM, COM1, CTIP, JWDS, SAE2, SCKL2

Product Description

RBBP8 is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 98kDa
• NCBI: 5932
• UniProt: A6NKN2
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

WB Suggested Anti-RBBP8 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human Placenta

Sample type: 1. HCT116 lysate (50ug)
2. MCF7 lysate (50ug)
3. rCtIP (30ng)
Primary Dilution: 1:1000
Secondary Antibody: anti-Rabbit IR700
Secondary Dilution: 1:5000
Image Submitted by: Nodar Makharashvili
University of Texas, Austin ,

Host: Rabbit
Target Name: RBBP8
Sample Type: Human Fetal Heart
Antibody Dilution: 1.0ug/ml

RBBP8 antibody - C-terminal region (ARP50887_P050) in Human Placenta using Western Blot