FZR1 Antibody - N-terminal region

Product Overview

• Article Name: FZR1 Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP51279_P050
• Supplier Catalog Number: ARP51279_P050
• Alternative Catalog Number: ASB-ARP51279_P050-25UL,ASB-ARP51279_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rat, Zebrafish
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FZR1
• Alternative Names: FZR, CDH1, FZR2, HCDH, HCDH1, CDC20C

Product Description

FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 55kDa
• NCBI: 51343
• UniProt: Q9UM11
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

WB Suggested Anti-FZR1 Antibody Titration: 0.2-1 ug/ml
Positive Control: 721_B cell lysateFZR1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells

Host: Rabbit
Target Name: FZR1
Sample Type: Human Fetal Brain
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: FZR1
Sample Type: Human Fetal Heart
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: FZR1
Sample Type: Human Fetal Lung
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: FZR1
Sample Type: Human Adult Placenta
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: FZR1
Sample Tissue: Human A549 Whole Cell
Antibody Dilution: 1ug/ml

FZR1 antibody - N-terminal region (ARP51279_P050) in Human 721_B using Western Blot