GP1BA Antibody - C-terminal region

Article Name:	GP1BA Antibody - C-terminal region
Biozol Catalog Number:	ASB-ARP51319_P050
Supplier Catalog Number:	ARP51319_P050
Alternative Catalog Number:	ASB-ARP51319_P050-25UL,ASB-ARP51319_P050-100UL
Manufacturer:	Aviva
Host:	Rabbit
Category:	Proteine/Peptide
Application:	WB
Species Reactivity:	Canine, Equine, Human, Mouse, Rabbit, Rat
Immunogen:	The immunogen is a synthetic peptide directed towards the C terminal region of human GP1BA
Conjugation:	Unconjugated
Alternative Names:	BSS, GP1B, VWDP, CD42B, GPIbA, BDPLT1, BDPLT3, DBPLT3, GPIbalpha, CD42b-alpha

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. GP1BA is the alpha subunit.Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Clonality:	Polyclonal
Concentration:	0.5 mg/ml
Molecular Weight:	72 kDa
NCBI:	2811
UniProt:	P07359
Form:	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

	WB Suggested Anti-GP1BA Antibody Titration: 0.2-1 ug/ml Positive Control: Jurkat cell lysate
	25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. Two isoforms contain this peptide sequence, including the 72 kDa canonical isoform and a 69 kDa alternate isoform. Additionally the full length protein can be processed into two chains of ~70 kDa and ~54 kDa forms.
	Host: Rabbit Target Name: GP1BA Sample Tissue: Human 786-0 Whole Cell Antibody Dilution: 1ug/ml
	Host: Rabbit Target Name: GP1BA Sample Tissue: Human HT1080 Whole Cell Antibody Dilution: 1ug/ml
	Host: Rabbit Target: GP1BA Positive control (+): A549 (N03) Negative control (-): RPMI-8226 (N12) Antibody concentration: 1ug/ml
	Host: Rabbit Target Name: GP1BA Sample Tissue: Human Hela Whole Cell Antibody Dilution: 3ug/ml
	GP1BA antibody - C-terminal region (ARP51319_P050) in Human Jurkat using Western Blot