TMPRSS6 Antibody - N-terminal region

Product Overview

• Article Name: TMPRSS6 Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP53188_P050
• Supplier Catalog Number: ARP53188_P050
• Alternative Catalog Number: ASB-ARP53188_P050-25UL,ASB-ARP53188_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: IHC, WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TMPRSS6
• Alternative Names: MT2, IRIDA

Product Description

TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter.The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 90 kDa
• NCBI: 164656
• UniProt: Q8IU80
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

Anti-TMPRSS6 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. TMPRSS6 Antibody ARP53188_P05 concentration 5 ug/ml.

WB Suggested Anti-TMPRSS6 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysate

Host: Rabbit
Target: TMPRSS6
Positive control (+): HepG2 (HG)
Negative control (-): MCF7 (N10)
Antibody concentration: 1.5ug/ml

TMPRSS6 antibody - N-terminal region (ARP53188_P050) in Human Jurkat using Western Blot