ERCC5 Antibody - N-terminal region

Product Overview

• Article Name: ERCC5 Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP54288_P050
• Supplier Catalog Number: ARP54288_P050
• Alternative Catalog Number: ASB-ARP54288_P050-25UL,ASB-ARP54288_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human ERCC5
• Alternative Names: XPG, UVDR, XPGC, COFS3, ERCM2, ERCC5-201

Product Description

This gene encodes a single-strand specific DNA endonuclease that makes the 3 incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 133 kDa
• NCBI: 2073
• UniProt: P28715
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

Host: Rabbit
Target Name: ERCC5
Sample Type: Ovary tumor lysates
Antibody Dilution: 1.0ug/ml

25 ug of the indicated Human whole cell extracts was loaded onto a 6-18% SDS-PAGE gel. 0.5 ug/mL of the antibody was used in this experiment. The peptide sequence is present in 47 kDa and 27 kDa isoforms. The protein may be modified by phosphorylation.

Host: Rabbit
Target Name: ERCC5
Sample Tissue: Human HT1080 Whole Cell
Antibody Dilution: 0.5ug/ml

ERCC5 Antibody - N-terminal region (ARP54288_P050) in Human Ovary tumor using Western Blot