LYN Antibody - N-terminal region

Product Overview

• Article Name: LYN Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP54696_P050
• Supplier Catalog Number: ARP54696_P050
• Alternative Catalog Number: ASB-ARP54696_P050-25UL,ASB-ARP54696_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat, Sheep
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LYN
• Alternative Names: JTK8, p53Lyn, p56Lyn

Product Description

LYN down regulates expression of stem cell growth factor receptor (KIT).LYN acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation.LYN acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. LYN acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents.LYN induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 58kDa
• NCBI: 4067
• UniProt: P07948
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

Rabbit Anti-LYN Antibody
Catalog Number: ARP54696_P050
Formalin Fixed Paraffin Embedded Tissue: Human Appendix (Colon) Tissue
Observed Staining: Plasma membrane
Primary Antibody Concentration: 1:600
Other Working Concentrations: N/A
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec

WB Suggested Anti-LYN Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Hela cell lysateLYN is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells

Host: Rabbit
Target Name: LYN
Sample Type: Human Fetal Brain
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: LYN
Sample Type: Human Fetal Heart
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: LYN
Sample Type: Human Fetal Lung
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: LYN
Sample Tissue: Mouse Brain
Antibody Dilution: 1ug/ml

Host: Mouse
Target Name: LYN
Sample Tissue: Mouse Brain
Antibody Dilution: 1ug/ml

LYN antibody - N-terminal region (ARP54696_P050) in Human HeLa using Western Blot