LOXL1 Antibody - N-terminal region

Product Overview

• Article Name: LOXL1 Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP54780_P050
• Supplier Catalog Number: ARP54780_P050
• Alternative Catalog Number: ASB-ARP54780_P050-25UL,ASB-ARP54780_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Bovine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LOXL1
• Alternative Names: LOL, LOXL

Product Description

LOXL1 is a member of the lysyl oxidase family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 63 kDa
• NCBI: 4016
• UniProt: Q08397
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

WB Suggested Anti-LOXL1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate

Host: Rabbit
Target: LOXL1
Positive control (+): Stomach tumor (T-ST)
Negative control (-): HepG2 (HG)
Antibody concentration: 3ug/ml

Host: Rabbit
Target Name: LOXL1
Sample Tissue: Human Jurkat Whole Cell
Antibody Dilution: 3ug/ml

Host: Rabbit
Target Name: LOXL1
Sample Tissue: Human OVCAR-3 Whole Cell
Antibody Dilution: 3ug/ml

Host: Rabbit
Target Name: LOXL1
Sample Tissue: Human 293T Whole Cell
Antibody Dilution: 3ug/ml

LOXL1 antibody - N-terminal region (ARP54780_P050) in Human HepG2 using Western Blot