PRAME Antibody - N-terminal region

Product Overview

• Article Name: PRAME Antibody - N-terminal region
• Biozol Catalog Number: ASB-ARP55982_P050
• Supplier Catalog Number: ARP55982_P050
• Alternative Catalog Number: ASB-ARP55982_P050-25UL,ASB-ARP55982_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Bovine, Equine, Human, Mouse, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PRAME
• Alternative Names: MAPE, OIP4, CT130, OIP-4

Product Description

PRAME functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. PRAME prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 56kDa
• NCBI: 23532
• UniProt: P78395
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Images

WB Suggested Anti-PRAME Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: HepG2 cell lysate

WB Suggested Anti-PRAME antibody Titration: 1 ug/mL
Sample Type: Human HepG2

WB Suggested Anti-PRAME antibody Titration: 1 ug/mL
Sample Type: Human K562

Host: Rabbit
Target: PRAME
Positive control (+): Hela (HL)
Negative control (-): Human lung (LU)
Antibody concentration: 1ug/ml

PRAME antibody - N-terminal region (ARP55982_P050) in Human HepG2 using Western Blot