ATP6V1C1 Antibody - N-terminal region

Article Name:	ATP6V1C1 Antibody - N-terminal region
Biozol Catalog Number:	ASB-ARP58589_P050
Supplier Catalog Number:	ARP58589_P050
Alternative Catalog Number:	ASB-ARP58589_P050-25UL,ASB-ARP58589_P050-100UL
Manufacturer:	Aviva
Host:	Rabbit
Category:	Proteine/Peptide
Application:	WB
Species Reactivity:	Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish
Immunogen:	The immunogen is a synthetic peptide directed towards the N terminal region of human ATP6V1C1
Alternative Names:	VATC, Vma5, ATP6C, ATP6D

ATP6V1C1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Clonality:	Polyclonal
Concentration:	0.5 mg/ml
Molecular Weight:	42kDa
NCBI:	528
UniProt:	P21283
Form:	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

	WB Suggested Anti-ATP6V1C1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: HepG2 cell lysate
	ARP58589-QC62779-190623-WB-image.jpg
	Host: Rabbit Target Name: ATP6V1C1 Sample Tissue: Human DLD1 Whole Cell Antibody Dilution: 1ug/ml
	Host: Rabbit Target Name: ATP6V1C1 Sample Tissue: Human 293T Whole Cell Antibody Dilution: 3ug/ml
	Host: Rabbit Target Name: ATP6V1C1 Sample Tissue: Human 786-0 Whole Cell Antibody Dilution: 3ug/ml
	ATP6V1C1 antibody - N-terminal region (ARP58589_P050) in Human HepG2 using Western Blot