AVPR2 Antibody - C-terminal region
Catalog Number:
ASB-ARP59538_P050
- Images (6)
| Article Name: | AVPR2 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP59538_P050 |
| Supplier Catalog Number: | ARP59538_P050 |
| Alternative Catalog Number: | ASB-ARP59538_P050-25UL,ASB-ARP59538_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human AVPR2 |
| Alternative Names: | DI1, DIR, NDI, V2R, ADHR, DIR3 |
| This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these extrarenal receptors are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. |
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25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment. |
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WB Suggested Anti-AVPR2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Hela cell lysate |
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Host: Rabbit Target Name: AVPR2 Sample Type: Human Fetal Lung Antibody Dilution: 1.0ug/ml |
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Host: Rabbit Target Name: AVPR2 Sample Type: Human Fetal Heart Antibody Dilution: 1.0ug/ml |
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Host: Rabbit Target: AVPR2 Positive control (+): THP-1 (N30) Negative control (-): A549 (N03) Antibody concentration: 1ug/ml |
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AVPR2 antibody - C-terminal region (ARP59538_P050) in Human HeLa using Western Blot |
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