CTNNB1 Antibody - C-terminal region

Product Overview

• Article Name: CTNNB1 Antibody - C-terminal region
• Biozol Catalog Number: ASB-ARP97342_P050
• Supplier Catalog Number: ARP97342_P050
• Alternative Catalog Number: ASB-ARP97342_P050-25UL,ASB-ARP97342_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Human
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CTNNB1
• Alternative Names: EVR7, CTNNB, MRD19, NEDSDV, armadillo

Product Description

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 86 kDa
• NCBI: 1499
• UniProt: P35222
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.