PML Antibody - middle region
Catalog Number:
ASB-ARP97377_P050
- Images (0)
| Article Name: | PML Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP97377_P050 |
| Supplier Catalog Number: | ARP97377_P050 |
| Alternative Catalog Number: | ASB-ARP97377_P050-25UL,ASB-ARP97377_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human PML |
| Alternative Names: | MYL, RNF71, PP8675, TRIM19 |
| The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the proteins central and C-terminal regions, all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Product Guarantee and Expert Support
