SP100 Antibody - C-terminal region
Catalog Number:
ASB-ARP97617_P050
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| Article Name: | SP100 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP97617_P050 |
| Supplier Catalog Number: | ARP97617_P050 |
| Alternative Catalog Number: | ASB-ARP97617_P050-25UL,ASB-ARP97617_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Mouse |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of mouse SP100 |
| Alternative Names: | A430075G10Rik |
| Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. May also play a role in infection by viruses through mechanisms that may involve chromatin and/or transcriptional regulation (By similarity). |
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