IL6ST Antibody - middle region
Catalog Number:
ASB-ARP97690_P050
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| Article Name: | IL6ST Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP97690_P050 |
| Supplier Catalog Number: | ARP97690_P050 |
| Alternative Catalog Number: | ASB-ARP97690_P050-25UL,ASB-ARP97690_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human IL6ST |
| Alternative Names: | CD130, GP130, HIES4, CDW130, IL-6RB, sGP130 |
| The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. |
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