PHOX2B Antibody - middle region
Catalog Number:
ASB-ARP97846_P050
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| Article Name: | PHOX2B Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP97846_P050 |
| Supplier Catalog Number: | ARP97846_P050 |
| Alternative Catalog Number: | ASB-ARP97846_P050-25UL,ASB-ARP97846_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human PHOX2B |
| Alternative Names: | CCHS, PMX2B, NBLST2, NBPhox |
| The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. |
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